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Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population

Xuan Guo1,2, Xiaohong Wang2, Yuan Wang3

  • 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

Oncotarget
|January 6, 2017
PubMed

Insights

Polymorphisms in the SMARCA4 gene, specifically rs11879293 and rs12232780, are associated with a reduced risk of coronary heart disease (CHD). This genetic association was observed in the Chinese Han population, suggesting SMARCA4 as a potential factor in CHD development.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • Coronary heart disease (CHD) remains a leading global cause of mortality.
  • Numerous single-nucleotide polymorphisms (SNPs) have been linked to CHD risk.
  • The association between SMARCA4 gene polymorphism and CHD requires further investigation.

Purpose of the Study:

  • To investigate the potential association between SMARCA4 gene polymorphism and the risk of developing coronary heart disease (CHD).
  • To identify specific SNPs within the SMARCA4 gene that may influence CHD susceptibility in the Chinese Han population.

Main Methods:

  • Genotyping of five CHD-relevant SNPs in 456 CHD cases and 685 controls from the Chinese Han population.
  • Statistical analyses including chi-squared tests, genetic model analysis, and haplotype analysis.
  • ANOVA was used to assess differences in continuous variables across genotypes.

Main Results:

  • Two SMARCA4 SNPs, rs11879293 (OR=0.74) and rs12232780 (OR=0.70), were significantly associated with a decreased risk of CHD.
  • These associations were observed under a log-additive model, adjusted for gender and age.
  • Significant differences in glucose, LDL-C, and HDL-C levels were noted among different genotypes of the identified SNPs.

Conclusions:

  • The study provides evidence supporting an association between SMARCA4 gene polymorphism and CHD development.
  • Specific SNPs in SMARCA4 may play a role in modulating CHD risk.
  • These findings contribute to understanding the genetic underpinnings of CHD in the Chinese Han population.
Abstract

Keywords:
Pathology SectionSMARCA4case-control studycoronary heart diseasegene polymorphisms

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