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Adult onset Still's disease
N Arber1, A Weinberger, R Fadila
1Department of Internal Medicine D, Beilinson Medical Center, Petah Tikva, Israel.
Clinical Rheumatology
|September 1, 1989
Summary
Adult onset of Still's disease presents with fever and joint pain. Liver function abnormalities in these patients resolved with corticosteroid treatment, suggesting a link to the core disease process.
Area of Science:
- Rheumatology
- Internal Medicine
- Clinical Immunology
Background:
- Adult onset Still's disease (AOSD) is a rare systemic inflammatory disorder.
- Early identification and management are crucial for patient outcomes.
Observation:
- Presents three cases of adult onset Still's disease.
- Common initial symptoms included fever, polyarthralgia, leukocytosis, neutrophilia, and elevated ESR.
- All patients exhibited abnormal liver function tests.
Findings:
- Hepatic abnormalities were observed in all presented AOSD cases.
- Liver function tests normalized after corticosteroid therapy.
Implications:
- Abnormal liver function tests in AOSD may indicate underlying systemic inflammation.
- Corticosteroid therapy appears effective in managing hepatic manifestations of AOSD.
- Further research into the pathogenesis of hepatic involvement in AOSD is warranted.