[Normal value and reference value range of brachial-ankle pulse wave velocity among Kailuan study population].

Area of Science:

• Cardiovascular Physiology
• Biomedical Engineering
• Public Health

Background:

• Brachial-ankle pulse wave velocity (baPWV) is a key indicator of arterial stiffness and cardiovascular risk.
• Establishing population-specific normal values for baPWV is essential for accurate clinical interpretation.

Purpose of the Study:

• To determine the normal and reference values of baPWV in a large Chinese population cohort.
• To analyze age- and gender-specific differences in baPWV.

Main Methods:

• Analysis of health check-up data from 20,622 individuals from the Kailuan study.
• Exclusion of participants with cardiovascular disease history, relevant medication use, or smoking.
• Selection of 9,109 healthy individuals for final baPWV reference value determination.

Main Results:

• Significant differences in baPWV and other physiological parameters were observed between males and females.
• Detailed age-stratified baPWV ranges (mean and 95% confidence intervals) were provided for both male and female populations.
• baPWV generally increased with age in both genders, with distinct values for each age group.

Conclusions:

• Normal baPWV values and ranges differ significantly based on age and gender within the Kailuan study population.
• These findings provide crucial reference data for assessing arterial stiffness in clinical practice.
• The study highlights the importance of considering demographic factors when interpreting baPWV measurements.