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Updated: Mar 9, 2026

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Optical Trap-Mediated High-Sensitivity Nanohole Array Biosensors with Random Nanospikes.

Takayasu Yoshikawa¹, Mamoru Tamura¹, Shiho Tokonami¹

¹Department of Physical Science, Graduate School of Science and ‡Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University , 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.

The Journal of Physical Chemistry Letters

|January 7, 2017

Summary

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This study introduces a novel biosensor using random nanospikes to enhance virus detection sensitivity. The system optically guides and traps viruses, enabling rapid and simple medical diagnosis and food inspection.

Area of Science:

Nanotechnology
Biophysics
Optics

Background:

Biosensors require high sensitivity for accurate detection.
Conventional nanohole arrays have limitations in sensitivity and detection range.
Optical forces can be utilized for manipulating nanoscale objects like viruses.

Purpose of the Study:

To develop a highly sensitive biosensor for virus detection.
To investigate the principle of light-driven operation enhanced by random nanospikes.
To enable rapid and simple virus detection for medical and food safety applications.

Main Methods:

Fabrication of a nanohole array surface with added random nanospikes.
Utilizing extraordinary optical transmission (EOT) modulated by nanospikes.

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Investigating light-induced forces for optical guiding and trapping of viruses.

Analyzing spectral peak shifts in EOT for enhanced sensitivity.

Main Results:

Random nanospikes enhance the light-induced force for optical guiding and trapping of viruses.
Nanospike-modulated EOT leads to significantly increased spectral peak shifts (hundreds of nanometers).
The system demonstrates a principle for enhanced biosensor sensitivity compared to conventional arrays.

Conclusions:

The developed biosensor offers a simple, rapid, and highly sensitive method for virus detection.
The findings facilitate convenient medical diagnosis and food inspection.
This approach leverages anomalous light-induced forces and nanospike-modulated EOT for improved performance.