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Gut Microbiota in Vascular Disease: Therapeutic Target?
A N Anbazhagan1, S Priyamvada1, M Priyadarshini2
1Department of Medicine, Division of Gastroenterology and Hepatology, College of Medicine, University of Illinois, Chicago, IL 60612. United States.
Current Vascular Pharmacology
|January 7, 2017
Summary
Gut microbes influence cardiovascular disease (CVD) risk through metabolic interactions. Targeting gut microbiota composition and activity offers potential anti-atherogenic therapies, but human studies are needed.
Area of Science:
- Microbiology
- Cardiovascular Science
- Metabolomics
Background:
- Gut microbiota significantly impacts host physiology, primarily via microbial metabolites.
- Predicting specific microbial roles in host metabolic states is challenging due to microbiota's dynamic nature.
Purpose of the Study:
- To review the role of gut microbiota in cardiovascular disorders (CVD).
- To explore potential therapeutic strategies targeting the gut microbiome for CVD prevention and treatment.
Main Methods:
- Literature search of PubMed for articles on gut microbiota and cardiovascular disease.
Main Results:
- Gut microbes directly contribute to cardiovascular disorders (CVD).
- Microbial metabolism, host immunity, and lipid metabolism interactions promote atherosclerosis.
- Strategies include targeting microbial composition and activity, such as using archaebiotics and high-fiber diets to modulate trimethylamine (TMA) and TMAO levels.
Conclusions:
- Targeting gut microbiota presents promising anti-atherogenic approaches.
- Extensive human research is required to validate these therapeutic strategies for CVD.
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