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Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways

Hua-Rong Li1,2, Jie Liu3, Shu-Ling Zhang1

  • 1Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.

BMC Complementary and Alternative Medicine
|January 7, 2017
PubMed
Abstract

Insights

Corilagin reduces inflammation in sepsis by down-regulating toll-like receptor 4 (TLR4) signaling pathways. This natural compound improves survival rates and decreases pro-inflammatory cytokines in cellular and animal models.

Area of Science:

  • Immunology
  • Pharmacology
  • Biochemistry

Background:

  • Sepsis is a critical clinical disorder with significant mortality.
  • Toll-like receptor 4 (TLR4) signaling is implicated in the pathogenesis of sepsis.
  • Investigating therapeutic interventions targeting TLR4 is crucial for sepsis management.

Purpose of the Study:

  • To investigate the therapeutic potential of Corilagin in sepsis.
  • To elucidate the effects of Corilagin on TLR4 signaling pathways in vitro and in vivo.

Main Methods:

  • Sepsis models were induced using lipopolysaccharide (LPS) and treated with Corilagin.
  • Quantitative real-time PCR and Western blot analyzed gene and protein expression of TLR4, MyD88, TRIF, and TRAF6.
  • Enzyme-linked immunosorbent assay (ELISA) measured levels of interleukin-6 (IL-6) and interleukin-1β (IL-1β).

Main Results:

  • Corilagin treatment significantly improved survival rates in sepsis models.
  • Down-regulation of mRNA and protein expression for TLR4, MyD88, TRIF, and TRAF6 was observed with Corilagin.
  • Pro-inflammatory cytokines IL-6 and IL-1β levels were significantly reduced in Corilagin-treated groups.

Conclusions:

  • Corilagin demonstrates significant anti-inflammatory effects in sepsis.
  • Down-regulation of TLR4 signaling molecules by Corilagin ameliorates excessive inflammation in sepsis.
  • Corilagin represents a potential therapeutic agent for sepsis treatment.
Keywords:
CorilaginEpsisPro-inflammatory cytokinesSignal pathwayTLR4

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