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Different clinical significance of FGFR1-4 expression between diffuse-type and intestinal-type gastric cancer

Mikito Inokuchi1, Hideaki Murase2, Sho Otsuki2

  • 1Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8519, Japan. m-inokuchi.srg2@tmd.ac.jp.

World Journal of Surgical Oncology
|January 7, 2017
PubMed
Abstract

Insights

Fibroblast growth factor receptor (FGFR) expression impacts gastric cancer progression. High FGFR4 correlates with poor survival in both diffuse-type (DGC) and intestinal-type gastric cancer (IGC), while FGFR1 and FGFR2 are linked to poorer outcomes only in DGC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Receptor tyrosine kinases (RTKs) drive tumor progression, with distinct activation patterns in diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC).
  • Fibroblast growth factor receptors (FGFRs) are key RTKs implicated in various cancers.
  • Previous research highlighted the clinical significance of FGFR1-4 in gastric cancer.

Purpose of the Study:

  • To reevaluate the distinct clinical significance of FGFR1-4 expression in DGC versus IGC.
  • To correlate FGFR expression levels with tumor progression and patient survival in both gastric cancer subtypes.

Main Methods:

  • Immunohistochemical analysis of FGFR1, FGFR2, FGFR3, and FGFR4 expression in 109 DGC and 100 IGC tumor samples.
  • Tumor samples were collected from patients who underwent gastrectomy between 2003 and 2007.

Main Results:

  • In DGC, high FGFR1, FGFR2, or FGFR4 expression correlated with increased tumor invasion, lymph-node metastasis, advanced pathological stage, and distant metastasis or recurrence.
  • Patients with high FGFR1, FGFR2, or FGFR4 expression in DGC exhibited significantly poorer disease-specific survival (DSS).
  • In IGC, only high FGFR4 expression was significantly associated with tumor progression and shorter DSS.

Conclusions:

  • High FGFR4 expression is a significant indicator of tumor progression and reduced survival in both DGC and IGC.
  • High FGFR1 and FGFR2 expression are associated with tumor progression and survival specifically in DGC.
  • These findings underscore the subtype-specific roles of FGFRs in gastric cancer pathogenesis and prognosis.
Keywords:
Fibroblast growth factor receptor 1Fibroblast growth factor receptor 2Fibroblast growth factor receptor 3Fibroblast growth factor receptor 4Gastric cancerImmunohistochemistry

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