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HIV and Nonischemic Heart Disease

Pravin Manga1, Keir McCutcheon1, Nqoba Tsabedze1

  • 1Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Journal of the American College of Cardiology
|January 7, 2017
PubMed

Insights

Human immunodeficiency virus (HIV)-associated heart disease affects multiple cardiac structures. Advances in combination antiretroviral therapy have influenced its prevalence and severity, improving understanding of diagnosis and management.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Human immunodeficiency virus (HIV) infection can lead to a wide range of cardiovascular complications.
  • These complications can affect the pericardium, myocardium, coronary arteries, pulmonary vasculature, valves, and systemic vasculature.

Purpose of the Study:

  • To review the current understanding of the pathogenesis and risk factors of HIV-associated heart disease.
  • To discuss recent advances in the diagnosis and management of these conditions.

Main Methods:

  • Literature review focusing on recent investigations.
  • Synthesis of epidemiological and pathophysiological data.

Main Results:

  • Combination antiretroviral therapy significantly impacts the prevalence and severity of HIV-associated cardiac conditions.
  • Improved understanding of the epidemiology and pathophysiology of HIV-associated cardiovascular disease.

Conclusions:

  • HIV infection presents diverse cardiovascular manifestations.
  • Therapeutic advancements have altered the landscape of HIV-associated heart disease, necessitating updated diagnostic and management strategies.

Keywords:
HIV-associated cardiomyopathyHIV-associated pulmonary artery hypertensionacquired immunodeficiency syndromeantiretroviral agents

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