Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis.

Oncogenesis·2013

Same author

A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion.

Oncogene·2013

Same author

Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors.

Oncogene·2012

Same author

Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes.

Oncogene·2007

Same author

Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice.

British journal of cancer·2004

Same author

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.

Nature medicine·2001

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Published on: October 6, 2016

Modeling Human Cancers in Drosophila.

M Sonoshita¹, R L Cagan²

¹Icahn School of Medicine at Mount Sinai, New York, NY, United States; Kyoto University Graduate School of Medicine, Kyoto, Japan.

Current Topics in Developmental Biology

|January 7, 2017

Summary

This summary is machine-generated.

Fruit fly (Drosophila) research offers novel insights into cancer biology and drug discovery. These studies help identify new cancer therapies and model patient-specific tumor genetics for personalized treatment approaches.

Keywords:

Cancer Drosophila Drug screening Genetic screening Invasion Metastasis Oncogene Personalized medicine Polypharmacology Tumor-suppressor gene

More Related Videos

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

Published on: September 11, 2013

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Published on: February 2, 2021

Related Experiment Videos

Last Updated: Mar 9, 2026

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Published on: October 6, 2016

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

Published on: September 11, 2013

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Published on: February 2, 2021

Area of Science:

Oncology
Genetics
Pharmacology

Background:

Cancer is a complex, multi-organ disease.
Whole-body animal models are crucial for cancer research and clinical translation.
Drosophila melanogaster serves as a powerful model organism in biological studies.

Purpose of the Study:

To review novel concepts in cancer biology, drug discovery, and patient therapy derived from Drosophila studies.
To highlight the utility of Drosophila in understanding oncogene and tumor suppressor gene functions in cancer formation.
To discuss the application of Drosophila in developing novel anticancer therapeutics and personalized medicine.

Main Methods:

Review of genetic studies in Drosophila focusing on cancer-related genes.
Analysis of Drosophila-based platforms for drug screening and development.
Exploration of Drosophila's role in modeling tumor genetic complexity for therapeutic strategies.

Main Results:

Drosophila studies have elucidated the roles of key oncogenes and tumor-suppressor genes in cancer.
The fruit fly model facilitates rapid identification of novel drug candidates for cancer treatment.
Drosophila platforms enable the modeling of individual tumor genetics for personalized therapy development.

Conclusions:

Drosophila is a valuable tool for advancing cancer biology research and drug discovery.
The model organism offers efficient platforms for identifying new anticancer therapeutics.
Drosophila research contributes to both fundamental cancer understanding and the development of personalized patient therapies.