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06:29
Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
Published on: May 2, 2025
877
Factors associated with long-term mortality after Fontan procedures: a systematic review
Tarek Alsaied1, Jouke P Bokma2,3, Mark E Engel4
1Children's Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Heart (British Cardiac Society)
|January 7, 2017
Summary
Late mortality after the Fontan operation is often due to heart/Fontan failure, arrhythmia, or respiratory failure. Identifying these risk factors is crucial for improving outcomes in the aging Fontan population.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
- Adult Congenital Heart Disease
Background:
- Limited data exists on long-term outcomes for the growing Fontan population.
- Variability in outcome measures complicates mortality risk assessment.
Purpose of the Study:
- To systematically review causes and determinants of late mortality in patients with Fontan circulation.
- To identify high-risk patients for improved risk stratification.
Main Methods:
- Systematic review of 28 studies including 6707 patients.
- Analysis of late mortality (postoperative year 1) and associated factors.
- Inclusion criteria: ≥90 patients or ≥20 late mortalities/transplants.
Main Results:
- 1000 deaths identified in 6707 patients with a mean follow-up of 8.23 years.
- Leading causes of death: heart/Fontan failure (22%), arrhythmia (16%), respiratory failure (15%), renal disease (12%), thrombosis/bleeding (10%).
- Nine categories of factors associated with late mortality were identified.
Conclusions:
- This study summarizes key causes and factors of late mortality post-Fontan operation.
- Findings aid in identifying high-risk individuals and guiding clinical risk stratification.
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