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Zinc Supplementation in Children with Asthma Exacerbation
Sanguansak Rerksuppaphol1, Lakkana Rerksuppaphol2
1Department of Pediatrics.
Pediatric Reports
|January 7, 2017
Summary
Zinc supplementation may rapidly reduce childhood asthma exacerbation severity. This study found that children receiving zinc alongside standard treatment showed quicker symptom improvement compared to placebo.
Area of Science:
- Pediatric Pulmonology
- Nutritional Immunology
- Clinical Nutrition
Background:
- Zinc deficiency is linked to increased asthma risk.
- The role of zinc supplementation in managing childhood asthma exacerbations requires further investigation.
Purpose of the Study:
- To assess the effectiveness of zinc supplementation in alleviating childhood asthma exacerbation severity.
- To evaluate zinc's impact as an adjuvant therapy to standard asthma treatment.
Main Methods:
- A randomized controlled trial involving 42 children hospitalized with asthma exacerbation.
- Participants received either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo, in addition to standard care.
- Asthma severity was measured using the Pediatric Respiratory Assessment Measure (PRAM) score.
Main Results:
- The zinc group exhibited a significantly faster reduction in PRAM scores at 24-hour (P=0.015) and 48-hour (P=0.042) intervals compared to the placebo group.
- No significant difference in PRAM scores was observed between children with low and normal serum zinc levels at baseline.
- Over half of the participating children (57.1%) presented with zinc deficiency at admission.
Conclusions:
- Zinc supplementation, when used adjunctively with standard treatment, can lead to a rapid decrease in asthma exacerbation severity in children.
- Further research may explore optimal zinc dosages and long-term effects in pediatric asthma management.
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