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Updated: Mar 9, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
A trombosis story and PRES
Vural Kartal1, Zeynep Zara1, Sema Yilmaz2
1Department of Pediatrics, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
Insights
Acute lymphoblastic leukemia treatment can cause thrombosis and posterior reversible encephalopathy syndrome (PRES). This case highlights PRES development, characterized by seizures, during chemotherapy for B-cell acute lymphoblastic leukemia.
Area of Science:
- Pediatric Oncology
- Neurology
- Hematology
Background:
- Trombosis is a known complication in children undergoing treatment for acute lymphoblastic leukemia (ALL), particularly with L-asparaginase.
- Posterior Reversible Encephalopathy Syndrome (PRES) is a neurological condition associated with various factors including chemotherapy.
- PRES is characterized by hypertension, headache, seizures, and altered consciousness, stemming from vasogenic edema in the brain.
Abstract:
Trombosis is seen in children with acute lymphoblastic leukemia during or after L-asparaginase treatment. Posterior reversible encephalopathy syndrome (PRES) is a complex syndrome characterized with sudden hypertension, headache, nausea, vomiting, alteration in the state of consciousness, vision defect and seizures. The cases related to this syndrome have been reportedly seen after eclampsia, organ transplantation, immunsuppressive treatments, autoimmune diseases and chemotherapy. Vasogenic edema occuring in the brain parencyhma constitues the basic pathophysiology. We present a case who developed seizures during treatment for B-cell acute lymphoblastic leukemia and diagnosed as posterior reversible encephalopathy.
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