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Related Experiment Video

Updated: Mar 9, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Neurosyphilis: a case report.

Tugce Toptan1, Betul Ozdilek1, Gulay Kenangil1

  • 1Department of Neurology, Erenkoy Training and Research Hospital for Neurologic and Psychiatric Disorders, Istanbul, Turkey.

Northern Clinics of Istanbul
|January 7, 2017
PubMed
Summary

Neurosyphilis, a chronic infection by Treponema pallidum, can cause severe psychiatric disorders. This case highlights its neuropsychiatric manifestations, emphasizing the need for awareness despite penicillin

Area of Science:

  • Infectious Diseases
  • Neurology
  • Psychiatry
Keywords:
Dementiageneral paresisneurosyphilispsychiatric manifestations

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Background:

  • Syphilis is a chronic, multisystem infection caused by the bacterium Treponema pallidum.
  • Neurosyphilis, a manifestation of syphilis, can lead to a range of psychiatric disorders, including depression, mania, psychosis, personality changes, delirium, and dementia.
  • While penicillin reduced syphilis incidence, its resurgence has been noted in conjunction with Human Immunodeficiency Virus (HIV) seropositivity.