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The impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
Murat Araz1, Aysen Bayrac2, Hilmi Ciftci3
1Department of Medical Oncology, Malatya State Hospital, Malatya, Turkey.
Insights
Diabetes significantly worsens left ventricular diastolic function in patients with hypertension. This impact is observed in both men and women, highlighting a critical link between diabetes and cardiovascular health.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Arterial hypertension and diabetes mellitus are significant risk factors for cardiovascular disease.
- Left ventricular diastolic dysfunction is an early indicator of cardiac compromise.
Purpose of the Study:
- To investigate the effect of diabetes mellitus on left ventricular diastolic function in patients with arterial hypertension.
- To assess whether diabetes exacerbates diastolic dysfunction in hypertensive individuals.
Main Methods:
- A cohort of 110 hypertensive patients (aged ≥40) were evaluated.
- Transthoracic echocardiography assessed left ventricular diastolic function.
- Patients with coronary artery disease or reduced ejection fraction were excluded.
Main Results:
- Diastolic dysfunction was more prevalent in patients with diabetes (81.25%) compared to those without (62.9%).
- The prevalence of diastolic dysfunction did not significantly differ between genders within the diabetic or non-diabetic groups.
Conclusions:
- Diabetes mellitus negatively impacts left ventricular diastolic function in the presence of arterial hypertension.
- This detrimental effect of diabetes on diastolic function is consistent across both male and female hypertensive patients.
Objective:
The aim of this study is to analyse the impact of diabetes mellitus on the left ventricular diastolic function in patients with arterial hypertension.
Methods:
Between July 2007 and July 2008, we enrolled patients aged ≥40 years who had hypertension with or without type 2 diabetes mellitus and unknown history of coronary artery disease who applied to 7.-8. internal medicine polyclinics of Goztepe Education and Training Hospital. Transthoracic echocardiography was used to assess the diastolic function. If patients with positive treadmill exercise test and/or EF ≤%50 in transthoracic echocardiography were excluded from the study. A total of 110 patients (males, n=42 38.2%, and females, n=68; 61.8%) with a mean age of 60.78 (±10.627) years were included in the study. For statistical analysis, SPSS 12.0 program and for the comparison of data chi-square test was used.
Results:
Diastolic dysfunction was significantly more prevalent in diabetes (81.25%) than those without diabetes group (62.9%) (p<0.05). In men, 35.9% in the DM(+) group and 41.1% in the DM(-) group had diastolic dysfunction. In women, 64.1% in the DM(+) group and 58.29% in the DM(-) group had diastolic dysfunction. In the evaluation based on gender, the difference male and female patients was not significant (p>0.05).
Conclusion:
Diabetes in association with hypertension has a negative effect on left ventricular diastolic function. This effect appears similar in men and women.
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