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A Mouse Fetal Skin Model of Scarless Wound Repair
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Fetal surgery: a critical review.

H Kitagawa1, K C Pringle2

  • 1Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8511, Japan. h2kita@marianna-u.ac.jp.

Pediatric Surgery International
|January 7, 2017
PubMed
Summary
This summary is machine-generated.

Accurate fetal diagnosis is key for therapeutic fetal surgery. Historically, open procedures evolved to minimally invasive techniques, improving fetal quality of life, notably for myelomeningocele.

Keywords:
Fetal diagnosisFetal prognosisFetal surgeryOpen procedurePercutaneous procedure

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Area of Science:

  • Medical Science
  • Surgical Innovation
  • Fetal Medicine

Background:

  • Therapeutic fetal surgery relies on accurate diagnosis and prognosis.
  • Early fetal surgeries in the 1960s targeted Rh isoimmunisation, evolving from open to percutaneous approaches.
  • Fetal ultrasound enabled diagnosis of congenital anomalies, leading to interventions with significant maternal risks.

Purpose of the Study:

  • To review the historical evolution of fetal surgery.
  • To examine the shift from open to minimally invasive fetal interventions.
  • To highlight the interplay between diagnostic accuracy and surgical approach.

Main Methods:

  • Historical review of fetal surgical procedures.
  • Analysis of diagnostic capabilities and their impact on surgical choices.
  • Comparison of open versus percutaneous (minimally invasive) techniques.

Main Results:

  • Fetal surgery has progressed from life-saving interventions to improving quality of life, exemplified by myelomeningocele repair.
  • Minimally invasive approaches have largely replaced open procedures due to reduced maternal morbidity.
  • The Management of Myelomeningocele (MOMS) Trial spurred widespread adoption of fetal repair for myelomeningocele.

Conclusions:

  • Accurate fetal diagnosis and prognosis remain critical for successful fetal interventions.
  • The trend in fetal surgery is towards minimally invasive techniques offering improved outcomes and reduced risks.
  • Continued research and technological advancements are essential for advancing fetal surgical care.