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Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy
Guang-Qian Xiao1, Pamela D Unger2
11 Keck Medical Center of the University of Southern California, Los Angeles, CA, USA.
International Journal of Surgical Pathology
|January 7, 2017
Summary
Signet ring cell prostatic intraepithelial neoplasia, a rare high-grade variant, was identified in isolation. This finding confirms its existence independent of invasive prostate cancer.
Area of Science:
- Uropathology
- Oncology
Background:
- High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor to prostate cancer.
- Signet ring cell morphology in HGPIN is considered a rare and speculative variant.
Observation:
- A unique case of isolated signet ring cell HGPIN was observed.
- This lesion was not associated with invasive prostate carcinoma on needle biopsy.
Findings:
- The presented case confirms the existence of signet ring cell HGPIN as a distinct entity.
- The study discusses differential diagnosis between HGPIN and intraductal carcinoma of the prostate.
Implications:
- This finding expands the understanding of HGPIN variants.
- Accurate differentiation is crucial for appropriate patient management and prognosis.
