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Updated: Mar 9, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy
Dongshan Zhang1,2, Xuan Xu1, Zheng Dong2,3
1a Department of Emergency Medicine , The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
Abstract:
Nephrotoxicity is a major side effect during chemotherapy with cisplatin and related platinum compounds. Previous work unveiled a role of PRKCD/PKCδ (protein kinase C delta) in cisplatin-induced nephrotoxicity; however, the underlying mechanism was largely unknown. Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.
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