[The clinical significance of anti-RNP antibody]

67 cases of anti-RNP antibody were reported in different patients with connective tissue disease. The high titre of anti-RNP antibody not only presents in patients with mixed connective tissue disease (MCTD), but also in individual patient with systemic lupus erythematosus (SLE). Anti-RNP antibody is usually associated with clinical manifestation of raynauds phenomena, myositis, and sclerodactyly. The clinical significance of anti-RNP antibody and the diagnosis about MCTD were discussed in this article.