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Related Experiment Videos

[Paroxysmal kinesigenic choreoathetosis].

J Z Wang

    Zhonghua Shen Jing Jing Shen Ke Za Zhi = Chinese Journal of Neurology and Psychiatry
    |February 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Paroxysmal kinesigenic choreoathetosis (PKC) involves brief, movement-triggered attacks, often starting in adolescence. Attacks typically resolve by age 30 and respond to medications like Dilantin and L-dopa.

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    Area of Science:

    • Neurology
    • Movement Disorders

    Context:

    • Paroxysmal kinesigenic choreoathetosis (PKC) is a rare neurological disorder characterized by sudden, involuntary movements.
    • This study examines a series of 20 PKC cases to better understand its clinical presentation and characteristics.

    Purpose:

    • To describe the clinical features, triggers, and natural history of paroxysmal kinesigenic choreoathetosis.
    • To investigate the potential role of alcohol in exacerbating PKC attacks.
    • To provide evidence supporting a functional basal ganglia disorder in PKC.

    Summary:

    • The study reports on 20 cases of PKC, predominantly sporadic (90%) and affecting males more than females (5.7:1 ratio).
    • Onset averaged 15 years, with attacks peaking during puberty (30-100/day), triggered by sudden movements and lasting under 3 minutes.

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  • Attacks showed spontaneous remission around age 20 and were responsive to Dilantin and L-dopa, with alcohol noted as a potential trigger.

    • Impact:

    • This research highlights specific movement triggers and the age-related course of PKC.
    • Findings suggest PKC may stem from a functional disorder within the basal ganglia.
    • The study underscores the importance of considering alcohol's effect on PKC exacerbation.