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Working Memory

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...

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Related Experiment Video

Updated: Mar 9, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Intrahemispheric theta rhythm desynchronization impairs working memory.

Ivan Alekseichuk, Stefanie Corinna Pabel, Andrea Antal

Restorative Neurology and Neuroscience

|January 7, 2017

Summary

This summary is machine-generated.

Disrupting frontoparietal theta phase connectivity impairs visual-spatial working memory. Desynchronization reduced memory performance and reaction time, while over-synchronization had no effect in healthy individuals.

Keywords:

Connectivity EEG frontoparietal network tACS theta rhythm working memory

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Published on: August 2, 2017

Area of Science:

Neuroscience
Cognitive Science

Background:

Large-scale brain connectivity is increasingly recognized as vital for working memory.
While anatomical and electrophysiological correlates are known, the functional role of connectivity remains unclear.

Purpose of the Study:

To investigate the causal role of theta phase connectivity in visual-spatial working memory.
To determine if manipulating frontoparietal network synchronization affects working memory.

Main Methods:

Utilized multi-electrode 6 Hz transcranial alternating current stimulation (tACS) to induce over- or de-synchronization in the frontoparietal network.
Employed behavioral testing and electroencephalography (EEG) to assess working memory performance and neural activity.

Main Results:

Frontoparietal intrahemispheric desynchronization led to decreased memory performance and increased reaction time.
EEG analysis showed reduced prefrontal-parietal theta phase connectivity following desynchronization.
Over-synchronization did not yield significant behavioral or electrophysiological changes.

Conclusions:

Demonstrated the feasibility of manipulating large-scale human brain networks using tACS.
Established that frontoparietal desynchronization disrupts theta phase connectivity and impairs visual-spatial working memory.