[Course and prognosis of multiple sclerosis. Report of 90 cases]

90 cases of multiple scleroses were studied in connexion with the course and prognosis of the disease. The course of this disease may be classified into 4 type: benign, remitting progressive, and chronic progressive types. Relapse took place in 75% of the patients. The frequency of relapse was on the average 0.45 time per year. Severe disability occurred mostly during the first five years. The present study suggested that the factors indicating relatively poor prognosis would be the onset at the age over 40 years, chronic insidious onset, early severe impairment of the pyramidal tract function and multiple involvement of the different systems in the CNS.