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Updated: Mar 9, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Emerging exposures of developmental toxicants
Mary S Wolff1, Jessie P Buckley, Stephanie M Engel
1aIcahn School of Medicine at Mount Sinai, New York, New York bUniversity of North Carolina, Chapel Hill, North Carolina cBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland dKeck School of Medicine, University of Southern California, Los Angeles, California eRollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Emerging chemicals in products pose risks to children
Area of Science:
- Environmental Health
- Toxicology
- Pediatric Health
Background:
- New products introduce novel chemicals with potential developmental toxicity.
- Widespread use of less-toxic chemicals can lead to significant population exposure.
- Exposure sources include consumer products, food, water, and air.
Purpose of the Study:
- Identify emerging developmental toxicants understudied in children's health.
- Assess risks associated with new chemical exposures.
- Inform strategies for preventing adverse health effects.
Main Methods:
- Literature review of PubMed-reported chemicals from the past decade.
- Analysis of exposure categories and frequency trends.
- Evaluation of biomonitoring and analytical methods.
Main Results:
- Identified eight exposure categories with numerous potential developmental toxicants.
- Examples include phthalates, phenols, sunscreens, pesticides, flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and polyphenols.
- Biomonitoring is recommended for exposure assessment of emerging chemicals.
Conclusions:
- A proactive biomonitoring strategy for emerging replacement chemicals is crucial.
- Characterizing widespread exposures is vital to prevent adverse developmental health effects.
- Early assessment can mitigate risks before chemicals become broadly disseminated.
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