Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Envisioning the development of a CRISPR-Cas mediated base editing strategy for a patient with a novel pathogenic <i>CRB1</i> single nucleotide variant.

Ophthalmic genetics·2022

Same author

A novel homozygous c.67C>T variant in retinol binding protein 4 (RBP4) associated with retinitis pigmentosa and childhood acne vulgaris.

Ophthalmic genetics·2020

Same author

First-in-human study of the safety and viability of intraocular robotic surgery.

Nature biomedical engineering·2018

Same author

Misdiagnosis of X-linked retinitis pigmentosa in a choroideremia patient with heavily pigmented fundi.

Ophthalmic genetics·2018

Same author

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina.

Gene therapy·2017

Same author

Technique of retinal gene therapy: delivery of viral vector into the subretinal space.

Eye (London, England)·2017

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

Electronic retinal implant surgery.

¹Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford and Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust and NIHR Biomedical Research Centre, Oxford, UK.

Eye (London, England)

|January 7, 2017

Summary

Retinal implants offer a potential treatment for blindness caused by outer retinal degeneration. Clinical trials show positive results, suggesting subretinal electronic devices can restore vision for those with retinitis pigmentosa.

More Related Videos

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

A Step by Step Protocol for Subretinal Surgery in Rabbits

A Step by Step Protocol for Subretinal Surgery in Rabbits

Published on: September 13, 2016

Related Experiment Videos

Last Updated: Mar 9, 2026

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

A Step by Step Protocol for Subretinal Surgery in Rabbits

A Step by Step Protocol for Subretinal Surgery in Rabbits

Published on: September 13, 2016

Area of Science:

Ophthalmology
Biomedical Engineering
Neuroscience

Background:

Outer retinal degeneration leads to irreversible blindness.
Inner retinal layers and optic nerve often remain functional.
Subretinal electronic devices offer a potential method for vision restoration.

Purpose of the Study:

To evaluate the efficacy of the first-generation Alpha IMS retinal implant.
To assess a next-generation retinal implant in an ongoing clinical trial.
To determine the suitability of retinal implants for treating retinitis pigmentosa.

Main Methods:

Overview of experiences with the Alpha IMS retinal implant.
Analysis of results from a multicentre clinical trial (NCT01024803).
Assessment of a second-generation device in a new clinical trial.

Main Results:

Positive outcomes observed in both first and second-generation device studies.
Retinal implants demonstrate potential for vision restoration in blind patients.
The Alpha IMS implant shows promise as a treatment for retinitis pigmentosa.

Conclusions:

Retinal implants should be considered a treatment option for retinitis pigmentosa-induced blindness.
Future technological advancements may broaden applications for earlier interventions and other diseases.
Subretinal electronic devices represent a significant step in treating degenerative blindness.