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Related Concept Videos

Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

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In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation.

Dongfei Liu1,2, Hongbo Zhang1,2, Salvatore Cito1

  • 1Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki , FI-00014 Helsinki, Finland.

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Summary

A novel microfluidic platform enables high-throughput production of stable core/shell nanocomposites. This method overcomes instability issues, offering a scalable solution for advanced material fabrication.

Keywords:
Sequential nanoprecipitationcore/shellnanoparticlesstabilizer freesuperfast

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Fabricating structured organic nanocomposites controllably, universally, and scalably remains a significant challenge.
  • Existing methods often struggle with instability issues of nanocomposite cores, necessitating stabilizers.

Discussion:

  • A microfluidic platform utilizing rapid sequential nanoprecipitation (milliseconds) has been developed for producing structured core/shell nanocomposites.
  • The multiplexed microfluidic design enables extremely short time intervals, preventing core instability without stabilizers.
  • This approach achieves high-throughput production (approximately 700 g/day per device).

Key Insights:

  • The developed platform facilitates the creation of stable core/shell nanocomposites with enhanced drug loading and dissolution kinetics.
  • It leverages the properties of drug nanocrystals and controlled release from polymer nanoparticles.
  • The process avoids the need for stabilizers, simplifying fabrication.

Outlook:

  • This technology offers a scalable and universal method for producing advanced nanocomposites.
  • Potential applications include drug delivery systems with improved efficacy and controlled release profiles.
  • Further research can explore diverse material combinations and complex architectures.