Related Experiment Video
Updated: Mar 9, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
21.0K
Scleritis Associated with SAPHO Syndrome: A Case Report
Rie Tanaka1, Keiichi Sakurai2, Toshikatsu Kaburaki1
1a Department of Ophthalmology , The University of Tokyo Hospital , Tokyo , Japan.
Ocular Immunology and Inflammation
|January 7, 2017
Summary
A rare case of scleritis, an eye inflammation, was diagnosed in a patient with Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome. Early recognition of systemic symptoms is crucial for timely diagnosis and treatment.
Area of Science:
- Ophthalmology
- Rheumatology
- Dermatology
Background:
- SAPHO syndrome is a rare autoinflammatory disorder characterized by the simultaneous occurrence of synovitis, acne, pustulosis, hyperostosis, and osteitis.
- Ocular manifestations, such as scleritis, are uncommon in SAPHO syndrome but can be the presenting sign.
Observation:
- A 31-year-old woman presented with bilateral painful red eyes, diagnosed as anterior diffuse scleritis via slit-lamp examination.
- The patient had a prior diagnosis of palmoplantar pustulosis and presented with hyperostosis of the sacroiliac joint and inflammation of sternoclavicular and sternocostal joints.
Findings:
- The patient was diagnosed with SAPHO syndrome after excluding other potential causes.
- This case highlights the infrequent association between scleritis and SAPHO syndrome.
Implications:
- Early identification of systemic symptoms is critical for the prompt diagnosis of SAPHO syndrome.
- Consultation with rheumatologists is essential for accurate diagnosis and management of patients with suspected SAPHO syndrome.
- Ophthalmologists should consider SAPHO syndrome in patients presenting with scleritis, especially those with a history of pustulosis or joint inflammation.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
790
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
790
01:26Nephrotic Syndrome II : Assessment and Medical Management
289
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
289