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Updated: Mar 9, 2026

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Complications Associated with Intra-Articular and Extra-Articular Corticosteroid Injections
Erin Honcharuk1, James Monica2
1Department of Orthopaedics, Rutgers-Robert Wood Johnson University Hospital, New Brunswick, New Jersey.
Abstract:
Side effects of corticosteroids can occur in association with both intra-articular and extra-articular injections. Less-severe reactions include skin reactions and flare responses. Although rare, worrisome complications such as infections, tendon ruptures, and osteonecrosis can occur. It is important to note the effect of corticosteroids on blood glucose levels, particularly for patients with diabetes. Corticosteroid injections have visual side effects with a known relation to central serous chorioretinopathy.
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