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Innervation of Human Intestinal Organoids
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Created of Warm Blood and Nerves: Restoring an Enteric Nervous System in Organoids
Christopher R Schlieve1, Tracy C Grikscheit1
1The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Cell Stem Cell
|January 7, 2017
Abstract:
The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.
