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Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity
G R Reddy1, G R Babu, P Reddanna
1Department of Zoology, S.V. University, India.
Ecotoxicology and Environmental Safety
|October 1, 1989
Abstract:
Substrate kinetics of succinate dehydrogenase (EC 1.3.99.1) were studied in the brain of control and dieldrin-treated albino rats. Dieldrin inhibited the enzyme activity to various degrees and also altered the Michaelis-Menten constant (Km) of the enzyme. Activation energy values (delta E) were increased, suggesting decreased maximal velocity Vmax, and the high Km obtained for the enzyme also revealed decreased enzyme-substrate affinity and masking of active sites by dieldrin.