Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

6.3K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-analysis of DNA methylation aging signatures in 17 human tissues.

Nature aging·2026
Same author

Development and validation of an LC-MS method for quantification of sex steroid hormones in skeletal muscle.

Steroids·2026
Same author

Trans-Inclusion in Sports: History, Scientific Evidence and Future Directions.

International journal of sports medicine·2026
Same author

Stress unmasks impaired endocrine coordination of glucose metabolism in dystrophin deficiency.

bioRxiv : the preprint server for biology·2026
Same author

Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex.

Skeletal muscle·2026
Same author

Effect of Social Media Advertisements on Adolescents' Sugar-Sweetened Beverage Choices: A Randomized Field Experiment.

Obesity (Silver Spring, Md.)·2026

Related Experiment Video

Updated: Mar 9, 2026

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

2.2K

MicroRNA expression patterns in post-natal mouse skeletal muscle development.

Séverine Lamon1, Evelyn Zacharewicz2, Lauren C Butchart3

  • 1Deakin University, School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (I-PAN), Geelong, Australia. severine.lamon@deakin.edu.au.

BMC Genomics
|January 8, 2017
PubMed
Summary

MicroRNAs (miRNAs) are crucial for muscle growth. This study reveals significant changes in miRNA expression during early post-natal mouse muscle development, identifying key miRNAs involved in muscle formation.

Keywords:
Cell differentiationCell proliferationGrowthMiRNAsMyogenesisSkeletal muscle

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.7K
Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
11:02

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

Published on: April 29, 2011

18.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

2.2K
Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.7K
Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
11:02

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

Published on: April 29, 2011

18.6K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are critical regulators of skeletal muscle development and homeostasis.
  • Most research on miRNA regulation in myogenesis is limited to tissue culture and embryogenesis.
  • Limited data exists on miRNA regulation during early post-natal mammalian skeletal muscle growth.

Purpose of the Study:

  • To investigate the expression patterns of miRNAs in mouse quadriceps muscle during early post-natal development.
  • To identify the putative roles of these miRNAs in myogenesis.
  • To understand miRNA regulation during the first 12 weeks of post-natal life.

Main Methods:

  • Utilized a high-throughput miRNA qPCR-based array.
  • Analyzed 768 miRNAs in mouse quadriceps muscle at ages 2 days, 2 weeks, 4 weeks, and 12 weeks.
  • Applied stringent statistical and bioinformatics analysis to expression data.

Main Results:

  • 46% of measured miRNAs were expressed in mouse quadriceps muscle during the first 12 weeks.
  • Observed significant, unprecedented changes in miRNA expression levels over time.
  • A majority of miRNAs showed decreased expression with post-natal muscle maturation; identified 2 miRNA subsets potentially regulating cell proliferation and differentiation.

Conclusions:

  • MiRNA expression in mouse quadriceps muscle undergoes substantial regulation during the first 12 weeks of life.
  • Identified novel, conserved miRNAs predicted to influence early muscle development.
  • Provides new insights into post-natal myogenesis and muscle regeneration in mammals.