Monocyte subsets in myocardial infarction: A review

Area of Science:

• Immunology
• Cardiovascular Research

Background:

• Monocytes are key components of the innate immune system involved in inflammation.
• Monocyte subsets are increasingly recognized for their roles in myocardial infarction (MI) pathogenesis and recovery.
• Distinct monocyte subsets exhibit unique phenotypic and dynamic patterns following MI, influencing inflammatory responses.

Purpose of the Study:

• To review current evidence on monocyte subset dynamics in human MI.
• To compare monocyte functions and dynamics in human MI with findings from mouse models.
• To assess the potential extrapolation of animal data to human MI contexts.

Main Methods:

• Systematic literature search of Medline and Embase databases up to April 5, 2016.
• Inclusion of observational studies and clinical trials on monocyte function in MI.
• Consideration of both human studies and extensive research from mouse models.

Main Results:

• Monocyte subsets exhibit differential roles in the inflammatory and reparative processes post-MI.
• Animal models provide insights into the complex dynamics of monocyte subsets during MI.
• Evidence suggests varying impacts of monocyte subsets on patient recovery after MI.

Conclusions:

• The relevance of animal model findings to human MI requires careful consideration.
• Understanding monocyte subset dynamics is crucial for elucidating MI pathophysiology.
• Further research is needed to fully translate findings from preclinical models to clinical applications in MI treatment.