Hetero-Diels-Alder approach to Bis(indolyl)methanes
Carla Grosso1, Ana L Cardoso1, Maria João Rodrigues2
1CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Abstract:
A novel synthetic approach to bis(indolyl)methanes has been established. Our one-pot synthetic strategy based on two consecutive hetero-Diels-Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles was extended to a range of new 1-hydroxyiminomethyl-bis(indolyl)methanes. Furthermore, a similar and broad range approach was applied to the synthesis of previously unknown 1-hydrazonomethyl-bis(indolyl)methanes. The biological evaluation of the new bis(indolyl)methanes as anti-cancer agents was investigated.
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