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The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects
Beibei Zhang1, Weiming Zhang2, Liang Yan3
1Department of Molecular Microbiology, Oslo University Hospital, Oslo, Norway.
Background:
The methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is closely related to the acute lymphoblastic leukaemia (ALL) indicated by many previous epidemiologic studies. However, their conclusions were still conflicting.
Methods:
Our aim is to evaluate their associations using a more comprehensive updated meta-analysis. Electronic searches were conducted to select published studies prior to February, 2016.
Results:
Totally, 39 case-control studies including 6551 ALL cases and 10,918 controls were selected in current meta-analysis. The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility.
Conclusions:
Our results indicate that the MTHFR C677T polymorphism may be a promising ALL biomarker and studies to explore the protein levels of the variants and their functional role are required for the definitive conclusions.
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