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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Improving the detection and diagnosis of congestive heart failure
L Wilhelmsen1, H Eriksson, K Svärdsudd
1Department of Medicine, Gothenburg University, Ostra Hospital, Sweden.
Insights
Early detection of heart failure is crucial for prevention. Identifying risk factors like obesity and hypertension, and understanding early symptoms are key to managing this insidious disease.
Area of Science:
- Cardiology
- Preventive Medicine
Background:
- Heart failure often has an insidious onset, progressing slowly over years.
- Current diagnostic criteria primarily identify manifest disease, hindering early detection and prevention.
- Understanding pathophysiological mechanisms and risk factors is essential for effective prevention strategies.
Purpose of the Study:
- To highlight the need for early detection criteria for heart failure.
- To identify principal causes and major risk factors associated with heart failure.
- To emphasize the importance of understanding underlying abnormalities for preventive treatments.
Main Methods:
- Review of current definitions and diagnostic limitations for heart failure.
- Identification of principal causes (coronary artery disease, hypertension) and major risk factors (obesity, smoking, diabetes).
- Analysis of a prospective study linking exercise-induced dyspnea to manifest heart failure.
Main Results:
- Current definitions are most specific for late-stage disease, limiting early case detection.
- Coronary artery disease and hypertension are primary causes in Western populations.
- Obesity, tobacco smoking, and diabetes mellitus are significant risk factors; exercise-induced dyspnea is a notable precursor symptom.
Conclusions:
- Early identification of heart failure symptoms and prompt management of risk factors are vital.
- A deeper understanding of biochemical and structural abnormalities is needed for improved preventive treatments.
- Focusing on early detection and risk factor modification can improve heart failure prevention efforts.
Abstract:
Early detection of heart failure requires criteria by which to define the initial stages of a syndrome which often has an insidious onset and which may progress slowly for many years. The most specific definitions of heart failure are those obtained towards the end of the disease process, but reliance upon these means that, although few cases are misclassified, only manifest cases can be detected. Since prevention is the ultimate goal, early detection of subjects at risk and a wider understanding of the pathophysiological mechanisms and risk factors are necessary. The principal causes of heart failure in the Western world are coronary artery disease and hypertension; valvular heart disease and other cardiac disorders are relatively uncommon causes. The major risk factors are obesity, tobacco smoking and diabetes mellitus, and in a prospective large-scale study we have also shown that individuals who develop manifest symptoms of heart failure often have a long history of exercise-induced dyspnoea. Clearly, identification of the early symptoms of heart failure and prompt treatment of risk factors such as hypertension and obesity are important objectives. However, a better understanding of the underlying biochemical and structural abnormalities would help to define more appropriate preventive treatments.
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