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Published on: June 25, 2019
Oxazolone-Induced Intestinal Inflammation in Adult Zebrafish
Sylvia Brugman1, Edward E S Nieuwenhuis2
1Animal Sciences Group, Cell Biology and Immunology, Wageningen University, De Elst 1, 6708, WD, Wageningen, The Netherlands. Sylvia.brugman@wur.nl.
Abstract:
Zebrafish are an excellent model for the study of intestinal immunity. The availability of several transgenic reporter fish for different innate and adaptive immune cells and the high homology in terms of gut function and morphology enables in depth analysis of the process of intestinal inflammation. Here, we describe a method to induce intestinal inflammation by intra-rectal injection of the hapten oxazolone in adult zebrafish.
