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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Are biventricular systolic functions impaired in patient with coronoray slow flow? A prospective study with three

Tuğba Kemaloğlu Öz1, Mehmet Eren2, Işıl Atasoy2

  • 1Department of Cardiology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey. tugbakemalogluoz@gmail.com.

The International Journal of Cardiovascular Imaging
|January 8, 2017
PubMed

Insights

Coronary slow flow phenomenon (CSFP) significantly impairs biventricular systolic function, reducing strain parameters and ejection fraction (EF) in both ventricles. This finding highlights CSFP

Area of Science:

  • Cardiology
  • Medical Imaging
  • Physiology

Background:

  • Coronary slow flow phenomenon (CSFP) affects myocardial dynamics.
  • Three-dimensional speckle-tracking echocardiography (3D-STE) offers advanced biventricular assessment.
  • The impact of CSFP on biventricular function requires further investigation.

Purpose of the Study:

  • To evaluate the effects of CSFP on biventricular systolic functions.
  • To utilize novel 3D-STE technology for comprehensive functional analysis.
  • To compare cardiac function in patients with CSFP versus healthy controls.

Main Methods:

  • Prospective enrollment of 40 CSFP patients and 40 controls.
  • Assessment of biventricular systolic function using 3D-STE.
  • Quantitative analysis of global longitudinal, circumferential, and radial strains, ejection fraction (EF), and volumes.

Main Results:

  • CSFP group showed significantly lower LV longitudinal, circumferential, and radial strains and EF.
  • LV end-systolic volume (ESV) was significantly higher in the CSFP group.
  • RV free wall, septal, and global longitudinal strains and RV EF were significantly reduced in CSFP patients.
  • No significant differences in LV/RV end-diastolic volume (EDV) or stroke volume (SV).
  • Strong correlation observed between myocardial strain and TIMI frame count.

Conclusions:

  • CSFP negatively impacts biventricular systolic function, affecting both strain parameters and ejection fraction.
  • 3D-STE is effective in quantifying these functional deficits caused by CSFP.
  • Findings suggest potential for early detection and management of cardiac dysfunction in CSFP.

Keywords:
Coronary slow flow phenomenonEchocardiographySpeckle trackingSystolic functionThree dimensional echocardiographyThree dimensional speckle tracking

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