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Updated: Mar 9, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Pathogenetic determinants in Kawasaki disease: the haematological point of view

Domenico Del Principe1, Donatella Pietraforte2, Lucrezia Gambardella1

  • 1Department of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.

Journal of Cellular and Molecular Medicine
|January 8, 2017
PubMed

Insights

Kawasaki disease, a vasculitis affecting children, can cause coronary artery issues. Research highlights hematological features as a key area for understanding its unclear causes.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Immunology

Background:

  • Kawasaki disease is a critical pediatric vasculitis leading to coronary artery lesions.
  • Characterized by fever, rash, and inflammation, it poses risks of ischemic heart disease.
  • Intravenous immunoglobulin treatment reduces coronary artery lesion incidence to under 5%.

Purpose of the Study:

  • To review current knowledge on Kawasaki disease pathogenesis.
  • To emphasize the emerging importance of hematological features in understanding the disease.
  • To explore potential microbial and genetic interactions in disease development.

Main Methods:

  • Literature review of existing research on Kawasaki disease.
  • Analysis of pathogenetic mechanisms and etiological factors.
  • Focus on recent findings related to hematological markers.

Main Results:

  • Kawasaki disease's exact cause remains unknown, with theories involving infection and genetics.
  • Coronary artery lesions are the most severe complication.
  • Hematological features are proposed as a significant area for future research.

Conclusions:

  • Understanding Kawasaki disease pathogenesis requires further investigation.
  • Hematological markers may offer new insights into disease mechanisms.
  • Interplay between genetic predisposition and microbial triggers is a leading hypothesis.

Keywords:
Kawasaki diseasebiomarkersetiopathogenesisgeneticshaematological featuresimmunityinfection

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