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Diabetes is associated with risk of postoperative cognitive dysfunction: A meta-analysis
I Feinkohl1, G Winterer2, T Pischon1,2,3
1Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin-Buch, Germany.
Patients with diabetes have an increased risk of postoperative cognitive dysfunction (POCD). Poorer glycemic control, indicated by higher hemoglobin A1c (HbA1c), may further elevate POCD risk in diabetic individuals.
Area of Science:
- Gerontology
- Anesthesiology
- Endocrinology
Background:
- Postoperative cognitive dysfunction (POCD) is common in older adults after surgery.
- Diabetes and glycemic dysregulation are linked to cognitive impairment.
- The specific role of diabetes in POCD risk is not well-established.
Purpose of the Study:
- To evaluate the association between diabetes, glycemic control, and hypoglycemia with POCD risk.
- To synthesize evidence from published epidemiological studies.
Main Methods:
- Systematic literature search of PubMed and Cochrane databases.
- Inclusion of longitudinal studies reporting on diabetes status, glycemic levels, or hypoglycemia and POCD risk.
- Meta-analysis conducted following MOOSE and PRISMA guidelines.
Main Results:
- 14 studies including 2642 patients were analyzed.
- Patients with diabetes showed a 1.26-fold increased risk of POCD.
- Higher hemoglobin A1c (HbA1c) levels correlated with increased POCD risk in diabetic patients.
Conclusions:
- Diabetes is associated with a higher risk of POCD.
- Glycemic control, measured by HbA1c, appears to influence POCD risk in diabetic individuals.
- Further research is needed on HbA1c in non-diabetics and hypoglycemia's role in POCD.
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