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Published on: February 28, 2012
Development of Left Atrial Thrombus After Coadministration of Dabigatran Etexilate and Phenytoin
Nicole Hager1, Jennifer Bolt1, Lori Albers1
1Department of Pharmacy, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada.
Abstract:
Dabigatran etexilate is a substrate of the P-glycoprotein (adenosine triphosphate-binding cassette subfamily B member 1) transport system and is subject to interactions with medications that induce or inhibit this system. The clinical relevance of the interaction between dabigatran and phenytoin has not been well described. We report a case of left atrial thrombus in a patient receiving concomitant dabigatran etexilate and phenytoin, which is a P-glycoprotein inducer. This case illustrates the potential clinical significance of the interactions of medications that affect P-glycoprotein and dabigatran.
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