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Quantifying Single Microvessel Permeability in Isolated Blood-perfused Rat Lung Preparation
Published on: June 30, 2014
The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung
1Department of Pharmacology, School of Pharmacy, University of the Western Cape, Bellville, Cape Province, South Africa.
Abstract:
Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2 receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator and predominant, dose-dependent constrictor components. Ketanserin showed no direct vasodilator effects but could completely antagonise the 5-HT-induced vasoconstrictor responses, suggesting that this response was 5-HT2 receptor-mediated.
