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Updated: Mar 9, 2026

Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus
Published on: April 19, 2024
Three new antitumor annonaceous acetogenins from the seeds of Annona squamosa
Chengyao Ma1, Qiwen Wang1, Yeye Shi1
1a Pharmaceutical Institute , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
Abstract:
Two new annonaceous acetogenins squamocin P (2) and annosquatin III (3) and one new ACG precursor dieporeticenin B (1) along with five known precursors (4-8) were isolated from the seeds of Annona squamosa. Their structures were ascertained by chemical methods and various spectral evidences. These compounds showed inhibitory effects against three multidrug-resistant (MDR) cancer cell lines. Compound 2 and 3 displayed selective cytotoxicity against SMMC 7721/T (IC50 0.435 and 1.79 μM) and MCF-7/ADR (IC50 values 3.34 and 4.04 μM).
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