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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Updated: Mar 9, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Using imaging as a biomarker for asthma.

Abhaya Trivedi1, Chase Hall1, Eric A Hoffman2

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo.

The Journal of Allergy and Clinical Immunology
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

Advanced imaging techniques like CT, MRI, and PET scans help identify asthma phenotypes and endotypes. These methods assess lung structure and function, aiding in personalized treatment strategies for asthma patients.

Keywords:
ImagingMRIPETbiomarkerchest CT

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Area of Science:

  • Pulmonology
  • Medical Imaging
  • Respiratory Medicine

Background:

  • Asthma evaluation traditionally relies on clinical parameters.
  • Understanding asthma pathophysiology requires detailed insights into lung structure and function.
  • Phenotypic and endotypic variations in asthma necessitate advanced diagnostic tools.

Purpose of the Study:

  • To review advancements in imaging techniques for asthma evaluation.
  • To highlight the role of imaging in identifying asthma phenotypes and endotypes.
  • To explore the potential of imaging as a biomarker for treatment response.

Main Methods:

  • Computed tomography (CT) for airway and lung density measurements.
  • Magnetic resonance imaging (MRI) with hyperpolarized 129Xe and 3He for distal lung ventilation.
  • Positron emission tomography (PET) for identifying lung inflammation.

Main Results:

  • CT measurements correlate with asthma severity and pathology, revealing unique phenotypes.
  • MRI with hyperpolarized gases measures small-airway disease.
  • PET imaging can identify and target lung inflammation in asthma.

Conclusions:

  • Imaging techniques offer valuable insights into asthma pathophysiology.
  • These techniques can identify specific asthma phenotypes and endotypes.
  • Imaging serves as a potential biomarker for assessing therapeutic responses in asthma.