[Effect of analgin on glucocorticoid receptors of the liver]

The experiments were performed on intact and phlogogenically exposed male Wistar rats (weighing 180-210 g). Glucocorticoid receptors were determined in a high-rate cytosol of the liver by using 3H-acetonide triamcinolone. Inflammation was induced by subplantar administration of formalin. In the model experiments, analgin (10(-2) M) decreased the level of glucocorticoid receptors in the rat liver cytosol. In a dose of 250 mg/kg intraperitoneally, analgin after 90 min decreased the liver content of glucocorticoid receptors and blood plasma concentrations of corticosterone in intact and phlogogenically exposed rats. The mechanism of the decrease of the content of glucocorticoid receptors in the liver and blood plasma concentrations of corticosterone in analgin-treated animals is discussed.