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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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Sublingual Immunotherapy Dosing Regimens: What Is Ideal?
Jay J Jin1, James T Li1, Ludger Klimek2
1Division of Allergic Diseases, Mayo Clinic, Rochester, Minn.
The Journal of Allergy and Clinical Immunology. in Practice
|January 10, 2017
Summary
Sublingual immunotherapy (SLIT) effectively treats allergic respiratory diseases like allergic rhinitis. Dosing varies by allergen and formulation, but studies show significant symptom reduction and reduced medication needs.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Respiratory Medicine
Background:
- Sublingual immunotherapy (SLIT) is an established treatment for allergic respiratory diseases.
- Various SLIT formulations are available globally for allergic rhinitis (AR).
Purpose of the Study:
- To review the dosing of selected SLIT formulations for allergic respiratory diseases.
- To provide practitioners with essential information on SLIT product dosing.
Main Methods:
- Review of clinical studies on grass, ragweed, and house dust mite SLIT formulations.
- Analysis of reported efficacy in reducing AR symptoms and medication use.
- Assessment of SLIT's impact on asthma exacerbation risk.
Main Results:
- Grass tablets (15-25 μg) reduced AR symptoms/medication use by 23-41%.
- Ragweed tablets (12 μg) and liquid extracts (50 μg) showed 26% and 43% reductions, respectively.
- House dust mite tablets demonstrated symptom reduction and reduced asthma exacerbation risk (HR 0.69).
Conclusions:
- SLIT formulations show efficacy in treating allergic rhinitis and reducing asthma exacerbations.
- Effective allergen doses range from 1.12 to 84 μg, but standardization is lacking.
- Practitioners should be aware of variability in allergen content and assays across SLIT products.
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