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Prospective evaluation of luteal phase length and natural fertility
Natalie M Crawford1, David A Pritchard2, Amy H Herring2
1Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Objective:
To evaluate the impact of a short luteal phase on fecundity.
Design:
Prospective time-to-pregnancy cohort study.
Setting:
Not applicable.
Patient(S):
Women trying to conceive, ages 30-44 years, without known infertility.
Intervention(S):
Daily diaries, ovulation prediction testing, standardized pregnancy testing.
Main Outcome Measure(S):
Subsequent cycle fecundity.
Result(S):
Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (≤11 days including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy.
Conclusion(S):
Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.
Clinical Trial Registration Number:
NCT01028365.
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