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Updated: Mar 9, 2026

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
Linking metabolic reprogramming to therapy resistance in cancer
Andrea Morandi1, Stefano Indraccolo2
1Department of Experimental and Clinical Biomedical Sciences, University of Florence, viale GB Morgagni 50, Florence 50134, Italy.
Abstract:
Metabolic rearrangements are essential to satisfy the different requirements of cancer cells during tumorigenesis and recent studies have highlighted a role for such metabolic reprogramming in response and adaptation to therapies. However, therapy-resistant experimental models have been described to be either glycolysis-dependent or OXPHOS-addicted. Here we discuss the recent literature on metabolic reprogramming of cancer in therapy resistance with a plausible explanation of the observed differences which collectively indicate that dis-regulated metabolic pathways could be considered potential therapeutic targets in tumors resistant to conventional therapy.
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