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Related Concept Videos

The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Types02:20

Blood Types

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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
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Rh Blood Group01:19

Rh Blood Group

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Related Experiment Video

Updated: Mar 9, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

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The Kidd (JK) Blood Group System.

Shaun Lawicki1, Randal B Covin2, Amy A Powers1

  • 1John A. Burns School of Medicine University of Hawai'i at Mānoa UH Pathology Residency Program Office, Honolulu, HI; Queens Medical Center, Honolulu, HI.

Transfusion Medicine Reviews
|January 10, 2017
PubMed
Summary

The Kidd blood group system involves Jka, Jkb, and Jk3 antigens, crucial for transfusions. Understanding the rare Kidd-null phenotype and associated antibodies is vital for preventing transfusion reactions and hemolytic disease.

Keywords:
Blood donorsErythrocyte membraneErythrocytesKidd blood group systemTransfusion medicineTransfusion reaction

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Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • The Kidd blood group system, discovered in 1951, comprises Jka, Jkb, and Jk3 antigens.
  • The Jk3 antigen is present in most individuals, except those with the rare Kidd-null phenotype.
  • The Kidd antigens are carried by a glycoprotein functioning as a urea transporter.

Purpose of the Study:

  • To review the Kidd blood group system, including its genetic basis and clinical significance.
  • To discuss transfusion reactions and challenges associated with Kidd antibodies.
  • To highlight the importance of the Kidd-null phenotype and management strategies.

Main Methods:

  • Literature review of the Kidd blood group system.
  • Analysis of genetic and protein structure of Kidd antigens.
  • Discussion of clinical implications, including transfusion reactions and hemolytic disease.

Main Results:

  • The Kidd glycoprotein (SLC14A1 gene) has 10 membrane-spanning domains.
  • Jka and Jkb antigens result from a single nucleotide polymorphism.
  • Kidd antibodies can cause acute and delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn.

Conclusions:

  • The Kidd blood group system presents complex transfusion challenges, particularly due to anti-Kidd antibodies.
  • The Kidd-null phenotype is clinically significant, necessitating careful management of blood donors.
  • Comprehensive understanding of the Kidd system is essential for safe transfusion practices.