Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary Change in Gut Specification in <i>Caenorhabditis</i> Centers on the GATA Factor ELT-3 in an Example of Developmental System Drift.

Journal of developmental biology·2023
Same author

The long isoform of the <i>C. elegans</i> ELT-3 GATA factor can specify endoderm when overexpressed.

microPublication biology·2023
Same author

The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network.

Development (Cambridge, England)·2022
Same author

Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development.

Development (Cambridge, England)·2022
Same author

Evolution of Developmental GATA Factors in Nematodes.

Journal of developmental biology·2020
Same author

Expression of a FRET-based ATP Biosensor in the <i>C. elegans</i> Intestine.

microPublication biology·2020

Related Experiment Video

Updated: Mar 9, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
08:01

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

6.9K

Gut development in C. elegans.

Morris F Maduro1

  • 1Biology Department, University of California, Riverside, CA 92521, United States.

Seminars in Cell & Developmental Biology
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

The nematode C. elegans gut develops from one cell into a 20-cell intestine. This review details its organogenesis, gene networks, and cell cycle regulation for future research.

Keywords:
C. elegansDevelopmentGATA factorsIntestineLumenMorphogenesis

More Related Videos

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.2K
Hand Dissection of Caenorhabditis elegans Intestines
05:41

Hand Dissection of Caenorhabditis elegans Intestines

Published on: September 13, 2022

4.2K

Related Experiment Videos

Last Updated: Mar 9, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
08:01

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

6.9K
Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.2K
Hand Dissection of Caenorhabditis elegans Intestines
05:41

Hand Dissection of Caenorhabditis elegans Intestines

Published on: September 13, 2022

4.2K

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The nematode Caenorhabditis elegans (C. elegans) intestine is a simple, 20-cell organ derived from a single embryonic precursor.
  • Its straightforward anatomy and genetic tractability make it an established model for studying organogenesis.

Purpose of the Study:

  • To review the key features of C. elegans gut development from the initial E progenitor cell to the mature 20-cell intestine.
  • To describe the gene regulatory network governing gut specification.
  • To highlight genes involved in organogenesis, lumen formation, and cell cycle control during gut development.

Main Methods:

  • Literature review of C. elegans gut development studies.
  • Analysis of gene regulatory networks and gene functions in organogenesis.

Main Results:

  • Detailed description of the developmental lineage from the E progenitor to the 20-cell intestine.
  • Identification of the core gene regulatory network essential for gut specification.
  • Summary of genes impacting organogenesis, lumen morphogenesis, and cell cycle progression.

Conclusions:

  • C. elegans gut development provides a robust model for understanding fundamental principles of organogenesis.
  • Further research is needed to fully elucidate the complex genetic and cellular mechanisms involved.