Related Experiment Video
Updated: Mar 9, 2026
10:50
Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
12.8K
TOWARDS THE DEVELOPMENT OF NOVEL THERAPEUTICS FOR PERIPHERAL ARTERY DISEASE.
Brian H Annex1, George A Beller1
1CHARLOTTE, VIRGINIA.
Transactions of the American Clinical and Climatological Association
|January 10, 2017
Summary
Peripheral artery disease (PAD) treatments are limited, with no new drugs since 1999. This research explores novel therapies, including innate immunity modulators, to promote new blood vessel growth for PAD patients.
Area of Science:
- Cardiovascular Science
- Immunology
- Regenerative Medicine
Background:
- Peripheral artery disease (PAD) is a common condition causing leg pain and amputation, with limited treatment options.
- Therapeutic angiogenesis, promoting new blood vessel growth, is a key goal for treating PAD.
- Previous attempts using cytokine growth factors have yielded disappointing results.
Purpose of the Study:
- To identify and review novel therapeutic approaches for PAD.
- To evaluate the potential of innate immunity modulators in treating PAD.
- To address the unmet need for effective PAD therapies.
Main Methods:
- Review of clinical and preclinical studies.
- Identification of novel therapeutic targets for PAD.
- Focus on innate immunity modulation as a therapeutic strategy.
Main Results:
- Cytokine growth factor therapies have shown limited success in PAD.
- Novel therapeutic strategies have been identified through laboratory research.
- Innate immunity modulation presents a promising avenue for PAD treatment.
Conclusions:
- There is a critical need for new PAD therapies.
- Innate immunity modulators offer a potential breakthrough for treating PAD.
- Further research into novel approaches is essential for improving patient outcomes.
Related Concept Videos
01:27Peripheral Artery Disease III: Interprofessional Care
472
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
472
01:26Peripheral Artery Disease IV: Nursing Management
519
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
519
01:30Peripheral Artery Disease I: Introduction
519
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
519
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
566
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
566
01:23Peripheral Artery Disease V: Postoperative Nursing Management
490
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
490
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
568
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
568