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Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
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LEUKOCYTE LIPID BODIES - STRUCTURE AND FUNCTION AS "EICOSASOMES".

Peter F Weller1

  • 1BOSTON, MASSACHUSETTS.

Transactions of the American Clinical and Climatological Association
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

Lipid bodies are specialized organelles in leukocytes that synthesize inflammatory mediators called eicosanoids. These distinct structures play a crucial role in regulating inflammatory responses within immune cells.

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Area of Science:

  • Cell Biology
  • Immunology
  • Biochemistry

Background:

  • Lipid bodies are cytoplasmic inclusions found in leukocytes, such as eosinophils and neutrophils.
  • They are associated with inflammatory processes and immune cell functions.

Purpose of the Study:

  • To investigate the formation and function of lipid bodies in leukocytes.
  • To characterize lipid bodies as distinct organelles involved in inflammatory mediator synthesis.

Main Methods:

  • Proteomic analysis
  • Ultrastructural studies
  • Immunolocalization of eicosanoids

Main Results:

  • Lipid bodies are inducible, endoplasmic reticulum-derived organelles containing membranes and ribosomes.
  • They contain enzymes for synthesizing cyclo-oxygenase- and lipoxygenase-derived eicosanoids.
  • Lipid bodies are discrete sites for eicosanoid synthesis and release, acting as paracrine and intracrine mediators of inflammation.

Conclusions:

  • Leukocyte lipid bodies are complex organelles distinct from adipocyte lipid droplets.
  • They play a critical role in regulating inflammatory responses through eicosanoid production.