Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.3K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.3K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

1.2K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.2K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

282
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
282

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HCV-specific CD4<sup>+</sup> T-cells are susceptible to HIV-1 and contribute to viral persistence during antiretroviral therapy.

EBioMedicine·2026
Same author

T- and B-cell-targeting DNA/MVA HCV vaccines induce strong and broad cellular and humoral immunity in mice and rhesus macaques.

Hepatology (Baltimore, Md.)·2026
Same author

IL-17A-induced NETs are profibrogenic in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Erratum: One step closer to a pan-genotypic hepatitis C vaccine.

Hepatology (Baltimore, Md.)·2025
Same author

Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease.

Nature communications·2025
Same author

One step closer to a pan-genotypic hepatitis C vaccine.

Hepatology (Baltimore, Md.)·2025

Related Experiment Video

Updated: Mar 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.9K

Type III Interferons in Hepatitis C Virus Infection.

Maude Boisvert1, Naglaa H Shoukry2

  • 1Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , Montréal, QC , Canada.

Frontiers in Immunology
|January 10, 2017
PubMed
Summary

Interferon-lambda (IFN-λ) cytokines, particularly IFN-λ3, play a crucial role in controlling Hepatitis C Virus (HCV) infection by inducing antiviral genes. Genetic variations in IFN-λ3 influence HCV clearance, highlighting its importance in immune response.

Keywords:
HCV clearanceIFN-λ3IFN-λ4SNPSVRhepatitis Cliver

More Related Videos

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

12.6K
Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

21.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.9K
A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

12.6K
Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

21.6K

Area of Science:

  • Immunology
  • Virology
  • Genetics

Background:

  • The interferon-lambda (IFN-λ) family, including IL-28A, IL-28B (IFN-λ3), and IL-29 (IFN-λ1), are type III cytokines crucial for innate immunity.
  • IFN-λ cytokines signal via the JAK-STAT pathway, inducing interferon-stimulated genes (ISGs) to establish an antiviral state, primarily in epithelial cells.
  • Genome-wide association studies link polymorphisms in the IL-28B gene (encoding IFN-λ3) to spontaneous and treatment-induced clearance of Hepatitis C Virus (HCV).

Approach:

  • Review of current knowledge on IFN-λ cytokines' role in HCV infection.
  • Analysis of IFN-λ3's direct antiviral activity against HCV replication.
  • Investigation into how IFN-λ3 and IFN-λ4 polymorphisms affect ISG induction in hepatocytes during HCV infection.

Key Points:

  • IFN-λ3 directly inhibits HCV replication and influences the pattern of ISGs induced in hepatocytes.
  • Polymorphisms in the IFN-λ3 gene are strongly associated with HCV clearance.
  • IFN-λ cytokines produced by dendritic cells modulate monocyte/macrophase inflammatory responses, bridging innate and adaptive immunity.

Conclusions:

  • IFN-λ cytokines are critical regulators of the immune response during acute and chronic HCV infections.
  • Understanding IFN-λ's mechanism, especially concerning genetic variations, is key to improving HCV treatment strategies.
  • IFN-λ's dual role in direct antiviral action and immune modulation underscores its significance in host defense against HCV.